Platform
NetMAPPR integrates computation, biology and chemistry to search expansively, validate rigorously, and prioritize for clinical and commercial potential
NetMAPPR Platform Discovery and Validation
![](https://enginebio.wpenginepowered.com/wp-content/uploads/2023/10/asd1sda.png)
Tightly Integrated and Iterative Computational and Experimental Platforms
![](https://enginebio.wpenginepowered.com/wp-content/uploads/2023/10/network-biology-1.png)
Mechanistic
Rationale
- Network biology establishing causal link between biomarker and target
- Understanding of sensitizing and resistance factors
Penetrance
- Confirmed in multiple cancer types
- Confirmed in multiple cell lines (genetic backgrounds)
In Vitro Pharmacology
- More sensitivity to pharmacological agent in presence of biomarker
- Isogenic cell lines
- Cell line / PDX panels
In Vivo Pharmacology
- Anti-tumor efficacy in biomarker mutant settings
- Isogenic cell line xenografts
- PDX models
Biomarker and Clinical Relevance
- Prevalence of biomarker mutation
- Link to worse prognosis
- Biomarker on approved diagnostic panel
Target and Drug Development
- Druggable for new drug discovery campaign
- Existing drug candidates available